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Evidence for determining parasitic factors in addition to host genetics and immune status in the outcome of murine Leishmania infantum visceral leishmaniasis
Author(s) -
Gangneux JeanPierre,
Sulahian Annie,
Honore Stéphanie,
Meneceur Pascale,
Derouin Francis,
Garin YvesJeanFrançois
Publication year - 2000
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.2000.00332.x
Subject(s) - leishmania infantum , biology , visceral leishmaniasis , leishmaniasis , immunology , congenic , immune system , leishmania , parasite hosting , host (biology) , virology , genetics , gene , world wide web , computer science
C.B‐17 SCID and congenic BALB/C mice were used to examine Leishmania infantum strain pathogenicity independently of host genetic factors. While parasite loads were significantly higher in immunodeficient mice than in immunocompetent mice, the kinetics of infection during a long‐term follow‐up were similar, suggesting that intrinsic parasitic factors also influence the outcome of L. infantum infection .