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Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum ‐infected mice
Author(s) -
Maruyama Haruhiko,
Osada Yoshio,
Yoshida Ayako,
Futakuchi Mitsuru,
Kawaguchi Hitoshi,
Zhang Renli,
Fu Jun,
Shirai Tomoyuki,
Kojima Somei,
Ohta Nobuo
Publication year - 2000
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.2000.00306.x
Subject(s) - schistosoma japonicum , biology , immunology , trichinella spiralis , strongyloides , nematode infection , strongyloidiasis , nematode , eosinophil , antigen , helminths , schistosomiasis , ecology , asthma
Mice infected with Schistosoma japonicum were resistant to the intestinal nematode, Strongyloides venezuelensis . The numbers of adult S. venezuelensis recovered from mice were significantly decreased when infections were given from 6 weeks after S. japonicum infection. Larval recovery from the lungs showed that significant numbers of subcutaneously inoculated S. venezuelensis larvae were eliminated by 3 days in S. japonicum ‐infected mice ( P < 0.0001), while histology revealed that this was associated with massive eosinophilic infiltration in the lungs. In addition, adult S. venezuelensis worms implanted in the duodenum of S. japonicum ‐infected mice could not establish in the intestine. This failure was associated with mucosal mastocytosis. Activation of eosinophils and intestinal mast cells was correlated with elevated expression of mRNA for interleukin (IL)‐3, IL‐4, and IL‐5 in S. japonicum ‐infected mice. Sera from S. japonicum ‐infected mice recognized S. venezuelensis larva antigens as strongly as those from S. venezuelensis ‐infected mice, although transfer of sera from S. japonicum ‐infected mice to normal recipient mice did not protect them from S. venezuelensis challenge infection. It was concluded that the mechanisms for larval killing and adult worm expulsion of S. venezuelensis in S. japonicum ‐infected mice were identical to those seen in infections with S. venezuelensis only .