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Reciprocal cross‐protection induced by sporozoite antigens SPAG‐1 from Theileria annulata and p67 from Theileria parva
Author(s) -
Hall Roger,
R.boulter Nicola,
Brown C.G.duncan,
Wilkie Gwen,
Kirvar Erol,
Nene Vish,
J.musoke Anthony,
J.glass Elizabeth,
Morzaria Subhash P.
Publication year - 2000
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.2000.00302.x
Subject(s) - biology , antigen , theileria parva , virology , homologous chromosome , theileria , homology (biology) , immunology , genetics , parasite hosting , gene , world wide web , computer science
Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life‐cycle, called SPAG‐1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross‐reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross‐species protection raising the prospect of a common vaccine in the future .