Premium
Differential immunoglobulin E and cytokine responses in BALB/c and C57Bl/6 mice during repeated infections with blood‐stage Plasmodium chabaudi malaria
Author(s) -
Helmby Helena,
TroyeBlomberg Marita
Publication year - 2000
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.2000.00295.x
Subject(s) - plasmodium chabaudi , immunology , immunoglobulin e , biology , antibody , parasitemia , cytokine , antigen , splenocyte , balb/c , immunoglobulin g , malaria , immune system , plasmodium falciparum
Repeated blood‐stage Plasmodium chabaudi chabaudi AS challenge infections in BALB/c and C57Bl/6 mice result in increased serum immunoglobulin (Ig) E levels and splenic cytokine production. The genetic background of the host influences both the cytokine response as well as the development of IgE antibodies. BALB/c mice showed high interleukin (IL)‐4 secretion from splenocytes after in‐vitro stimulation with malaria antigen after repeated P. chabaudi challenges and this was closely followed by higher levels of total IgE. Despite slightly elevated serum IgE levels, splenocytes from C57Bl/6 mice did not secrete any detectable IL‐4 but produced interferon (IFN)‐γ in response to malaria antigen‐stimulation in vitro . These data suggest that induction of IgE antibodies during murine malaria infection is genetically regulated .