Premium
Interferon‐γ‐independent CD8 + T cell‐mediated protective anti‐malaria immunity elicited by recombinant adenovirus
Author(s) -
Rodrigues,
Claassen,
Myeong Soo Lee,
Marcus D. Wilson,
Nussenzweig,
Moriya Tsuji
Publication year - 2000
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.2000.00289.x
Subject(s) - plasmodium yoelii , immunity , biology , virology , immunology , plasmodium falciparum , cd8 , interferon gamma , malaria , immunization , recombinant dna , interferon , cellular immunity , t cell , immune system , parasitemia , gene , biochemistry
Recombinant adenovirus, expressing the CS protein of Plasmodium yoelii , AdPyCS, was shown to induce a comparable degree of T cell‐mediated protection against malaria as a single dose of irradiated P. yoelii sporozoites, causing inhibition of liver stage development. We now report that differently from sporozoite‐induced immunity, interferon (IFN)‐γ does not mediate the protective immunity induced by AdPyCS, since a similar degree of protection was observed in AdPyCS immunized mice lacking IFN‐γ −/− and the IFN‐γ receptor (IFN‐γR −/− ) compared to that in wild‐type mice. Depletion of CD8 + T cells from these immunized mice almost completely abolished the AdPyCS‐induced immunity, indicating that the immunization with AdPyCS induces CD8 + T cell‐mediated protective anti‐malaria immunity, which is independent of IFN‐γ .