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Vaccination of Manchego lambs against Haemonchus contortus with a somatic fraction (p26/23) of adult parasites
Author(s) -
DomínguezToraño Inés A.,
Cuquerella Montserrat,
GómezMuñoz Mª.teresa,
Méndez Susana,
J.fernándezPérez Francisco,
M.alunda José
Publication year - 2000
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.2000.00283.x
Subject(s) - haemonchus contortus , biology , vaccination , feces , parasite hosting , immunology , somatic cell , antibody response , antibody , physiology , veterinary medicine , helminths , medicine , microbiology and biotechnology , biochemistry , world wide web , computer science , gene
A low molecular weight fraction from adult Haemonchus contortus containing two peptides (p26/23) was used to vaccinate Manchego female lambs between 3.5 and 5 months of age. Immunizing injections were given three times on days 0, 14 and 28 of the experiment. On day 43, lambs were challenged with 400 third stage larvae/kg live weight. Vaccination induced a lengthening of prepatent periods, significant reduction (> 60%) in mean faecal egg counts and smaller variations in packed cell volume values. At necropsy, average worm burden in the vaccinated lambs was significantly lower (61.6%) than that found in unvaccinated challenged animals. A clear correlation was found between protection and serum antibody response in immunized lambs .