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Adversarial relationship between the Leishmania lipophosphoglycan and protein kinase C of host macrophages[Note 1. Paper presented at the British Society for Immunology Congress, ...]
Author(s) -
Turco Salvatore J.
Publication year - 1999
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.1999.00266.x
Subject(s) - lipophosphoglycan , glycoconjugate , leishmania , biology , protein kinase c , microbiology and biotechnology , macrophage , virulence , inhibitory postsynaptic potential , kinase , parasite hosting , immunology , glycoprotein , leishmaniasis , genetics , biochemistry , neuroscience , in vitro , gene , leishmania donovani , visceral leishmaniasis , world wide web , computer science
The dominant glycoconjugate on the cell surface of all Leishmania promastigotes is an unusual glycoconjugate named lipophosphoglycan (LPG). Its relative abundance, unique structure, and cellular location have implicated LPG as an essential virulence determinant. One feature of LPG resides in its strong inhibitory effect on the activity of protein kinase C (PKC) of host macrophages. This article summarizes the evidence that LPG is inhibitory toward PKC activation in macrophages and discusses the implication of such inhibition on intramacrophage survival of the parasite .