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Definition of T cell epitopes within the 19 kDa carboxylterminal fragment of Plasmodium yoelii merozoite surface protein 1 (MSP1 19 ) and their role in immunity to malaria
Author(s) -
TIAN JINGHUI,
GOOD MICHAEL F.,
HIRUNPETCHARAT CHAKRIT,
KUMAR SANJAI,
LING IRENE T.,
JACKSON DAVID,
COOPER JUAN,
LUKSZO JAN,
COLIGAN JOHN,
AHLERS JEFFERY,
SAUL ALLAN,
BERZOFSKY JAY A.,
HOLDER ANTHONY A.,
MILLER LOUIS H.,
KASLOW DAVID C.
Publication year - 1998
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.1998.00138.x
Subject(s) - epitope , plasmodium yoelii , biology , effector , immunization , priming (agriculture) , virology , antibody , immunity , immunology , t cell , immune system , plasmodium falciparum , malaria , parasitemia , botany , germination
MSP1 19 is one of the leading malaria vaccine candidates. However, the mechanism of protection is not clear. To determine whether MSP1 19 ‐specific effector T cells can control parasitaemia, we analysed the specificity of T cells induced following immunization with recombinant forms of P. yoelii MSP1 19 and asked whether they could protect mice. There was no evidence that effector T cells were capable of protecting since: (1) immunization of mice with yMSP1 19 , but not defined epitopes, was able to induce protection; and (2) long term MSP1 19 ‐specific CD4 + T cell lines were incapable of adoptively transferring protection. In contrast, priming mice with the T cell epitopes resulted in a rapid anamnestic antibody response to MSP1 19 after either challenge with MSP1 19 or parasite. Thus, MSP1 19 contains multiple T cell epitopes but such epitopes are the targets of helper T cells for antibody response but not of identified effector T cells capable of controlling parasitaemia .