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Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice
Author(s) -
MARÉCHAL P.,
LE GOFF L.,
HOFFMAN W.,
RAPP J.,
OSWALD I.P.,
OMBROUCK C.,
TAYLOR D.W.,
BAIN O.,
PETIT G.
Publication year - 1997
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.1997.d01-209.x
Subject(s) - immune system , immunology , biology , antigen , spleen , antibody , ratón , antibody response
Comparisons were made between the immune responses evoked during the course of chronic and patent infections of Litomosoides sigmodontis in susceptible BALB/c mice and non‐patent infections in resistant B10.D2 mice. Early antigen specific responses of spleen cells were weak in both mouse strains. However, by day 58 post infection a strong Th2 response, as determined by production of IL‐4, IL‐5 and IL‐10, was observed in BALB/c mice but not in B10.D2 mice. Antibody responses seemed to appear sooner in B10.D2 than in BALB/c mice, and these differentially recognised two antigens of 15 kD and 80 kD.