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Paramyosin: a candidate vaccine antigen against Schistosoma japonicum
Author(s) -
RAMIREZ BERNADETTE L.,
KURTIS JONATHAN D.,
WIEST PETER M.,
ARIAS PERCIVAL,
ALIGUI FE,
ACOSTA LUZ,
PETERS PIERRE,
OLDS G.RICHARD
Publication year - 1996
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.1996.d01-4.x
Subject(s) - schistosoma japonicum , biology , schistosomiasis , adjuvant , antigen , schistosomiasis japonica , immunology , immunization , vaccination , schistosoma , schistosoma mansoni , parasite hosting , helminthiasis , vaccine efficacy , virology , helminths , world wide web , computer science
Paramyosin, a 97 kDa myofibrillar protein, is a candidate vaccine antigen for prevention of infection with the human parasite Schistosoma mansoni . To determine if paramyosin would also induce protection against Schistosoma japonicum , paramyosin was biochemically purified from S. japonicum adult worms. SDS‐PAGE demonstrated a single protein with a molecular weight of 97 kDa. In four separate experiments, vaccination of mice with S. japonicum paramyosin without adjuvant induced significant resistance (62%–86%, P < 0.001) against cercarial challenge as compared to controls. These data suggest that S. japonicum paramyosin may represent a candidate vaccine for immunization against schistosomiasis japonica.