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Presence of antibodies in the aqueous humour and cerebrospinal fluid during Leishmania infections in dogs. Pathological features at the central nervous system
Author(s) -
GarciaAlonso M.,
Nieto C.G.,
Blanco A.,
Requena J.M.,
Alonso C.,
Navarrete I.
Publication year - 1996
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1046/j.1365-3024.1996.d01-28.x
Subject(s) - cerebrospinal fluid , choroid plexus , leishmania , pathology , biology , antigen , blood–brain barrier , leishmania infantum , antibody , interstitial fluid , immunology , central nervous system , leishmaniasis , medicine , neuroscience , visceral leishmaniasis , parasite hosting , world wide web , computer science
In the present paper we show that in dogs, naturally infected with Leishmania infantum , the aqueous humour and the cerebrospinal fluid contain anti‐ Leishmania IgGs and that the specificity of antigen recognition of these fluids is similar to that of the sera. We also show that in the encephalon and cerebellum of these dogs there is a pathological sponge‐like reaction accompanied by neuronal degeneration, mobilization of glial cells together with accumulation of amyloid deposits. The interstitial and intravascular deposition of IgGs and Leishmania antigens in choroid plexus suggest that in these animals there is a failure of the blood‐cerebrospinal and ciliary bodies filtration barriers which may allow the transfer of anti‐ Leishmania IgGs from the blood stream to these fluids. We suggest that the failure of the blood‐cerebrospinal barrier and the in situ concentration of anti‐ Leishmania IgGs and antigens in brain tissues may predispose to the pathological features detected in this compartment.