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A lower rate of preterm birth after clotrimazole therapy during pregnancy
Author(s) -
Andr̀ew E. Czeizel,
Magda Rockenbauer
Publication year - 1999
Publication title -
paediatric and perinatal epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 88
eISSN - 1365-3016
pISSN - 0269-5022
DOI - 10.1046/j.1365-3016.1999.00157.x
Subject(s) - medicine , clotrimazole , pregnancy , obstetrics , dermatology , antifungal , genetics , biology
Topical or vaginal clotrimazole treatment during pregnancy was evaluated in the large population‐based control data set of the Hungarian Case–Control Surveillance of Congenital Abnormalities, 1980–92. The database comprised 32 804 control non‐malformed newborn infants, 7.7% of whom were born to mothers who had received clotrimazole treatment during pregnancy. An increase in mean gestational age among exposed vs. unexposed was found. It is postulated that the use of clotrimazole during pregnancy reduced significantly the proportion of preterm births because of the effective treatment of genital infections caused by candidiasis in pregnant women.