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Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV‐1‐associated dementia
Author(s) -
Boven L. A.,
Middel J.,
Verhoef J.,
De Groot C. J. A.,
Nottet H. S. L. M.
Publication year - 2000
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1046/j.1365-2990.2000.00255.x
Subject(s) - cd68 , tight junction , infiltration (hvac) , monocyte , dementia , blood–brain barrier , microglia , pathology , immunohistochemistry , biology , immunology , microbiology and biotechnology , medicine , disease , inflammation , central nervous system , neuroscience , materials science , composite material
In human immunodeficiency virus (HIV)‐1‐associated dementia (HAD), consequences of interactions between infiltrating monocytes and brain endothelial cells are not yet fully understood. This study investigated whether the blood–brain barrier is affected in brain tissue of patients suffering from HAD and whether it was possible to find a correlation with the presence or absence of monocytic cells, which have been suggested to play a major role in HAD. Immunohistochemical analysis for zonula occludens 1, a tight junction protein, and CD68, a macrophage marker, revealed that loss of tight junction immunoreactivity was highly correlated with monocyte infiltration and with HAD. This suggests that the presence of perivascular macrophages cells is associated with breakdown of the blood–brain barrier thereby facilitating infiltration of more monocytic cells hence enhancing disease progression.