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Effects of ileal bile salts on fasting small intestinal and gallbladder motility
Author(s) -
Van Ooteghem N. A. M.,
Samsom M.,
Van Erpecum K. J.,
Van BergeHenegouwen G. P.
Publication year - 2002
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1046/j.1365-2982.2002.00356.x
Subject(s) - migrating motor complex , medicine , enterohepatic circulation , gastroenterology , ileum , duodenum , gallbladder , jejunum , motility , cholestyramine , sphincter of oddi , bile acid , chemistry , endocrinology , cholesterol , biology , genetics
In the fasting state, gallbladder emptying is related to phase III of the intestinal migrating motor complex. The effects of ileal infusion of mixed taurocholate‐phospholipid micelles on fasting small intestinal motility (by a 17‐channel catheter with side holes located in duodenum, jejunum and ileum) and gallbladder motility (by ultrasound) were investigated in eight healthy volunteers. After bile salt depletion by cholestyramine, 0.9% NaCl or mixed micelles were infused in the ileum during phase II of the migrating motor complex. Time to onset of subsequent phase III was significantly shorter after infusion of mixed micelles compared with 0.9% NaCl (32 ± 5 min vs. 60 ± 5 min, P = 0.01). Distal to the infusion port, numbers of pressure waves and their amplitudes were significantly lower during bile salt infusion compared with 15 min before infusion (11 ± 6 per 15 min vs. 21 ± 8 per 15 min, and 2.4 ± 0.6 kPa vs. 2.8 ± 0.5 kPa, respectively). Micellar infusions increased fasting gallbladder volumes to 170 ± 5% of starting volumes (P < 0.0001). In conclusion, ileal infusion of mixed micelles influences the timing of phase III of the intestinal migrating motor complex, inhibits ileal motility and increases fasting gallbladder volumes. These findings may have important consequences for enterohepatic circulation of bile salts.