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Biogenesis of inner membrane proteins in Escherichia coli
Author(s) -
De Gier JanWillem,
Luirink Joen
Publication year - 2001
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.2001.02392.x
Subject(s) - periplasmic space , inner membrane , biogenesis , biology , translocon , membrane protein , bacterial outer membrane , microbiology and biotechnology , escherichia coli , membrane transport protein , transport protein , biochemistry , membrane , mitochondrion , gene
For a long time, it was generally assumed that the biogenesis of inner membrane proteins in Escherichia coli occurs spontaneously, and that only the translocation of large periplasmic domains requires the aid of a protein machinery, the Sec translocon. However, evidence obtained in recent years indicates that most, if not all, inner membrane proteins require the assistance of protein factors to reach their native conformation in the membrane. Here, we review and discuss recent advances in our understanding of the biogenesis of inner membrane proteins in E. coli .