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Understanding the enzymology of archaeal DNA replication: progress in form and function
Author(s) -
MacNeill Stuart A.
Publication year - 2001
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.2001.02390.x
Subject(s) - biology , dna replication , archaea , genetics , dna , gene , origin recognition complex , genome , computational biology , function (biology) , licensing factor , origin of replication , eukaryotic dna replication
The analysis of completed archaeal genome sequences led to the identification of a set of approximately 10–20 genes whose protein products were inferred to be involved in chromosomal DNA replication. Until recently, however, little was known of the biochemical properties of these proteins. Here, I review recent progress in this area brought about by biochemical and structural analysis. Aside from shedding considerable new light on the molecular machinery of DNA replication in the archaea, the results of these studies also present new opportunities for understanding the molecular events of chromosomal DNA replication in eukaryotic cells.