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Type III export: new uses for an old pathway
Author(s) -
Plano Gregory V.,
Day James B.,
Ferracci Franco
Publication year - 2001
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.2001.02354.x
Subject(s) - secretion , biology , extracellular , secretory protein , microbiology and biotechnology , secretory pathway , bacteria , biochemistry , computational biology , genetics , endoplasmic reticulum , golgi apparatus
Gram‐negative bacteria use type III secretion (TTS) systems to translocate proteins into the extracellular environment or directly into eukaryotic cells. These complex secretory systems are assembled from over 20 different structural proteins, including 10 that have counterparts in the flagellar export pathway. Secretion substrates are directed to the TTS machinery via mRNA and/or amino acid secretion signals. TTS chaperones bind to select secretion substrates and assist in the export process. Recent progress in the understanding of TTS is reviewed.