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The Tat protein export pathway
Author(s) -
Berks Ben C.,
Sargent Frank,
Palmer Tracy
Publication year - 2000
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.2000.01719.x
Subject(s) - biology , twin arginine translocation pathway , cytoplasm , arginine , transport protein , microbiology and biotechnology , chromosomal translocation , signal peptide , translocon , biochemistry , peptide sequence , computational biology , amino acid , gene
The Tat ( t win‐ a rginine t ranslocation) system is a bacterial protein export pathway with the remarkable ability to transport folded proteins across the cytoplasmic membrane. Preproteins are directed to the Tat pathway by signal peptides that bear a characteristic sequence motif, which includes consecutive arginine residues. Here, we review recent progress on the characterization of the Tat system and critically discuss the structure and operation of this major new bacterial protein export pathway.