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Termination of DNA replication of bacterial and plasmid chromosomes
Author(s) -
Bussiere Dirksen E.,
Bastia Deepak
Publication year - 1999
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1999.01287.x
Subject(s) - ter protein , biology , terminator (solar) , control of chromosome duplication , dna replication , helicase , replication factor c , prokaryotic dna replication , genetics , pre replication complex , minichromosome maintenance , plasmid , origin recognition complex , eukaryotic dna replication , origin of replication , microbiology and biotechnology , dna , rna , gene , ionosphere , physics , astronomy
Sequence‐specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis ‐acting ter site and a trans ‐acting replication terminator protein. The interaction of a terminator protein with the ter site creates a protein–DNA complex that arrests replication forks in a polar fashion by antagonizing the action of the replicative helicase (thereby exhibiting a contrahelicase activity). Terminator proteins also arrest RNA polymerases in a polar fashion. Passage of an RNA transcript through a terminus from the non‐blocking direction abrogates replication termination function, a mechanism that is likely to be used in conditional termini or replication check points.