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Mycobacterium tuberculosis phagosome
Author(s) -
Deretic V.,
Fratti R. A.
Publication year - 1999
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1999.01279.x
Subject(s) - phagosome , biology , mycobacterium tuberculosis , context (archaeology) , biogenesis , microbiology and biotechnology , tuberculosis , organelle biogenesis , organelle , mycobacterium , intracellular , bacteria , genetics , gene , pathology , medicine , paleontology
The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment‐specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.