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The cytoplasmic domain of FtsK protein is required for resolution of chromosome dimers
Author(s) -
Steiner Walter,
Liu Guowen,
Donachie William D.,
Kuempel Peter
Publication year - 1999
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1999.01198.x
Subject(s) - biology , recombination , cell division , homologous recombination , homologous chromosome , chromosome , genetics , cytoplasm , locus (genetics) , recombinase , chromosome segregation , escherichia coli , recombineering , microbiology and biotechnology , cell , gene
Chromosome dimers, formed by homologous recombination between sister chromosomes, normally require cell division to be resolved into monomers by site‐specific recombination at the dif locus of Escherichia coli . We report here that it is not in fact cell division per se that is required for dimer resolution but the action of the cytoplasmic domain of FtsK, which is a bifunctional protein required both for cell division and for chromosome partition.