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SOS and Mayday: multiple inducible mutagenic pathways in Escherichia coli
Author(s) -
Humayun M. Zafri
Publication year - 1998
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1998.01120.x
Subject(s) - biology , escherichia coli , escherichia coli proteins , enterobacteriaceae , computational biology , microbiology and biotechnology , genetics , gene
Environmental and physiological stress conditions can transiently alter the fidelity of DNA replication. The DNA damage‐mediated SOS response in Escherichia coli is the best‐known example of such an ‘inducible mutagenesis’ or ‘transient mutator’ pathway. Emerging evidence suggests the existence of a number of other stress‐inducible pathways that also affect the fidelity of replication. Among the more provocative recent findings are UVM, an SOS‐independent damage‐inducible mutagenic pathway, and a new recA ‐dependent but umuD/C ‐independent pathway that appears to be provoked by translational stress. These findings alter our view of inducible mutagenesis, and anticipate the existence of previously unrecognized links between protein synthesis and DNA replication.