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DNA repair in Mycobacterium tuberculosis . What have we learnt from the genome sequence?
Author(s) -
Mizrahi Valerie,
Andersen Susan J.
Publication year - 1998
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1998.01038.x
Subject(s) - biology , genetics , gene , mutagenesis , dna repair , nucleotide excision repair , genome , mycobacterium tuberculosis , whole genome sequencing , dna mismatch repair , dna , base excision repair , dna damage , mutation , tuberculosis , medicine , pathology
The genome sequence of Mycobacterium tuberculosis was analysed by searching for homologues of genes known to be involved in the reversal or repair of DNA damage in Escherichia coli and related organisms. Genes necessary to perform nucleotide excision repair (NER), base excision repair (BER), recombination, and SOS repair and mutagenesis were identified. In particular, all of the genes known to be directly involved in the repair of oxidative and alkylative damage are present in M. tuberculosis . In contrast, we failed to identify homologues of genes involved in mismatch repair. This finding has potentially significant implications with respect to genome stability, strain variability at repeat loci and the emergence of chromosomally encoded drug resistance mutations.