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The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae
Author(s) -
Didion Thomas,
Regenberg Birgitte,
Jørgensen Marianne U.,
KiellandBrandt Morten C.,
Andersen Helge A.
Publication year - 1998
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1998.00714.x
Subject(s) - permease , biology , open reading frame , transporter , saccharomyces cerevisiae , gene , amino acid , leucine , biochemistry , amino acid transporter , peptide sequence , membrane transport protein , integral membrane protein , genetics , membrane protein , membrane
Amino acid transporters of the yeast plasma membrane (permeases) belong to a family of integral membrane proteins with pronounced structural similarity. We present evidence that a member of this family, encoded by the open reading frame (ORF) YDR160w ( SSY1 ), is required for the expression of a set of transporter genes. Thus, deletion of the SSY1 gene causes loss of leucine‐inducible transcription of the amino acid permease genes BAP2 , TAT1 and BAP3 (ORF YDR046c) and the peptide transporter, PTR2 . D ‐leucine can generate the signal without entering the cell. We propose that Ssy1p is situated in the plasma membrane and is involved in sensing leucine in the medium.