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Getting greasy: how transmembrane polypeptide segments integrate into the lipid bilayer
Author(s) -
Von Heijne Gunnar
Publication year - 1997
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1997.3351702.x
Subject(s) - transmembrane protein , biology , integral membrane protein , membrane protein , protein targeting , lipid bilayer , microbiology and biotechnology , biogenesis , peripheral membrane protein , transport protein , chromosomal translocation , transmembrane domain , membrane , biochemistry , biophysics , gene , receptor
Many integral membrane proteins use the same translocation machinery for membrane insertion as secretory proteins use to get across the membrane. This requires that transmembrane segments can be discriminated from other parts of the protein during membrane translocation, and further requires that the transmembrane segments can be moved laterally out of the translocation channel into the surrounding lipid. The molecular basis for this remarkable intramembraneous sorting event is a major focus of current studies of membrane protein biogenesis.