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DnaA initiator—also a transcription factor
Author(s) -
Messer Walter,
Weigel Christoph
Publication year - 1997
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1046/j.1365-2958.1997.3171678.x
Subject(s) - dnaa , biology , dna binding protein , transcription factor , transcription (linguistics) , genetics , promoter , dna , gene , microbiology and biotechnology , dna replication , computational biology , gene expression , linguistics , philosophy
The replication‐initiator protein DnaA is ubiquitous in the eubacterial world. It binds to an asymmetric 9 bp consensus DNA sequence, the DnaA box. Besides its primary function as an initiator, it acts as a transcription factor that represses or activates several genes, or terminates transcription, depending on the location and arrangement of DnaA boxes.