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Genetics of refractoriness to Plasmodium falciparum in the mosquito Anopheles stephensi
Author(s) -
VAN GEMERT GEERTJAN,
VAN DE VEGTEBOLMER MARGA G.,
JANSEN RITSERT C.
Publication year - 1998
Publication title -
medical and veterinary entomology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 82
eISSN - 1365-2915
pISSN - 0269-283X
DOI - 10.1046/j.1365-2915.1998.00122.x
Subject(s) - anopheles stephensi , biology , plasmodium falciparum , parasite hosting , malaria , genetics , locus (genetics) , anopheles , gene , gametocyte , refractory period , extranuclear inheritance , virology , plasmodium (life cycle) , immunology , aedes aegypti , ecology , medicine , larva , world wide web , computer science , mitochondrial dna
We previously selected a line of the malaria vector mosquito Anopheles stephensi refractory (resistant) to the human malaria parasite Plasmodium falciparum , using in vitro infections with P. falciparum gametocytes. This report presents data on the genetic background of refractoriness. The results of F 1 ‐crosses and backcrosses show that refractoriness to P. falciparum in our A. stephensi line is autosomal and semi‐dominant to susceptibility. The expression of refractoriness is apparently affected by a cytoplasmic factor. Interpretation of data from the crosses by quantitative trait locus analysis shows that one gene or two unlinked interacting autosomal genes, or groups of closely linked genes, are involved.