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Evidence for the genetic basis of non‐response in mice
Author(s) -
Waters J. A.
Publication year - 1998
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1046/j.1365-2893.1998.0050s2001.x
Subject(s) - immunogenicity , antigen , immune system , immunology , hbcag , biology , population , virology , hepatitis b virus , virus , medicine , hbsag , environmental health
In the murine model the immune response to both the hepatitis B envelope and nucleocapsid antigens are linked to the MHC class II haplotype but they are independently restricted. Although in a human outbred population non‐response is less likely, the host genetic environment may be important in determining the level of response to vaccine and inclusion of antigens apart from the S antigen may improve protection. The inclusion of HBcAg in vaccine remains controversial since, despite its high immunogenicity, the Th‐cell response to this antigen may have a role in the down regulation of the immune response to HBV so promoting persistence.