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Hepatitis C virus genotypes in Australia
Author(s) -
McCaw R.,
Moaven L.,
Locarnini S. A.,
Bowden D. S.
Publication year - 1997
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1046/j.1365-2893.1997.00060.x
Subject(s) - genotype , genotyping , hepatitis c virus , incidence (geometry) , virology , biology , polymerase chain reaction , ns5b , hepatitis c , hepacivirus , virus , genetics , gene , physics , optics
Summary. The relative distribution of Australian hepatitis C virus (HCV) genotypes was determined for 500 isolates. Genotyping was performed using a commercial reverse phase hybridization assay after amplification of the 5′ untranslated region of HCV by the polymerase chain reaction. Australian isolates comprised, predominantly, genotype 1 (55%) and genotype 3 (38%) with genotype 2 accounting for only 7%. Genotype 3a was the most common subtype. When the major risk groups of injecting drug users or transfusion‐acquired hepatitis C were compared, there was a significantly higher incidence of genotype 1b in the transfusion‐acquired group ( P < 0.03). When the age of the patients was analysed, genotype 3a was more prevalent in the 21–40‐year age group than the 41–60‐year age group ( P < 0.05). There was no significant difference in genotype distribution between males and females. HCV genotypes 1, 2 and 3 are most often found in developed countries but the relatively high prevalence of genotype 3a in Australia is unusual.