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Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats
Author(s) -
Waxman S.,
Rodríguez C.,
González F.,
De Vicente M. L.,
San Andrés M. I.,
San Andrés M. D.
Publication year - 2001
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1046/j.1365-2885.2001.00357.x
Subject(s) - pharmacokinetics , volume of distribution , bioavailability , high performance liquid chromatography , chemistry , pharmacology , half life , drug administration , zoology , chromatography , medicine , biology
The pharmacokinetic behavior of marbofloxacin was studied in goats after single‐dose intravenous (i.v.) and intramuscular (i.m.) administrations of 2 mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography (HPLC) and the data collected were subjected to compartmental and noncompartmental kinetic analysis. This compound presented a relatively high volume of distribution ( V ss =1.31 L/kg), which suggests good tissue penetration, and a total body clearance ( Cl ) of 0.23 L/kg·h, which is related to a long elimination half‐life ( t 1/2 β =7.18 h and 6.70 h i.v. and i.m., respectively). Pharmacokinetic parameters were not significantly different between both routes of administration. Marbofloxacin was rapidly absorbed after i.m. administration ( T max =0.9 h) and had high bioavailability ( F =100.74%).