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Pharmacokinetics of ricobendazole in calves
Author(s) -
Formentini E. A.,
Mestorino O. N.,
Mariño E. L.,
Errecalde J. O.
Publication year - 2001
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1046/j.1365-2885.2001.00328.x
Subject(s) - pharmacokinetics , metabolite , albendazole , chemistry , chromatography , plasma concentration , pharmacology , high performance liquid chromatography , biology , medicine , biochemistry , surgery
The pharmacokinetics of ricobendazole (RBZ) and its major metabolite albendazole sulphone (ABZSO 2 ) were studied in six calves, after administration of RBZ (7.5 mg/kg), using a 10% experimental solution by the intravenous (i.v.) route, a 10% commercial solution by the subcutaneous (s.c.) route, and a 10% experimental suspension by the intraruminal (i.r.) route. Blood samples were drawn during a 60‐h period. Plasma drug and metabolite concentrations were determined by HPLC. The pharmacokinetic evaluation in each case was prepared by weighted least‐squares nonlinear regression analysis. Ricobendazole i.v. data were best fitted by a two‐compartment model. The best pharmacokinetic exponents and coefficients were estimated, and the pharmacokinetic variables for RBZ and ABZSO 2 were calculated from them. Similar patterns of plasma disposition were found for RBZ after i.r. and s.c. administration, suggesting delayed release from the s.c. site resembling the slow release of the drug from the rumen.