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Pharmacokinetics of oxytetracycline in the red pacu ( Colossoma brachypomum ) following different routes of administration
Author(s) -
Doi Am,
Stoskopf Mk,
Gregory A. Lewbart
Publication year - 1998
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1046/j.1365-2885.1998.00162.x
Subject(s) - oxytetracycline , pharmacokinetics , aeromonas salmonicida , bioavailability , pacu , high performance liquid chromatography , plasma concentration , pharmacology , antibiotics , chemistry , medicine , microbiology and biotechnology , biology , fish <actinopterygii> , chromatography , anesthesia , fishery
Oxytetracycline (OTC) pharmacokinetics were studied in the red pacu ( Colossoma brachypomum ) following intravenous (i.v.) and intramuscular (i.m.) administration at a dose of 5 mg/kg body weight. OTC plasma concentrations were determined by high‐performance‐liquid‐chromatography (HPLC). A non‐compartmental model was used to describe plasma drug disposition after OTC administration. Following i.m. administration, the elimination half‐life ( t ½ ) was 62.65 ± 1.25 h and the bioavailability was 49.80 ± 0.01%. After i.v. administration the t ½ was 50.97 ± 2.99 h, the V d was 534.11 ± 38.58 mL/kg, and CI b was 0.121 ± 0.003 mL/min.kg. The 5 mg/kg i.v. dose used in this experiment resulted in up to 48 h plasma concentrations of OTC above the reported MIC values for some strains of fish pathogens such as Aeromonas hydrophila , A. liquefaciens , A. salmonicida , Cytophaga columnaris , Edwardsiella ictaluri , Vibrio anguillarium , V. ordalii , V. salmonicida and Yeersinia ruckeri . These MIC values are below the susceptible range (4 μg/mL) listed by the National Committee for Clinical Laboratory Standards (NCCLS) as determined by the NCCLS susceptibility interpretive criteria.