Premium
Pharmacokinetics, metabolism and urinary detection time of flunixin after intravenous administration in camels
Author(s) -
Wasfi I.A.,
Boni N.S.,
Abdel Hadi A.A.,
ElGhazali M.,
Zorob O.,
Alkatheeri N.A.,
Barezaiq I.M.
Publication year - 1998
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1046/j.1365-2885.1998.00122.x
Subject(s) - pharmacokinetics , metabolite , chemistry , urine , body weight , chromatography , pharmacology , endocrinology , medicine , biochemistry
The pharmacokinetics of flunixin were determined after an intravenous dose of 1.1 mg/kg body weight in six camels and 2.2 mg/kg body weight in four camels. The data obtained (mean ± SEM) for the low and high dose, respectively, were as follows: The elimination half‐lives ( t ½β ) were 3.76 ± 0.24 and 4.08 ± 0.49 h, the steady state volumes of distribution ( V d ss ) were 320.61 ± 38.53 and 348.84 ± 35.36 mL/kg body weight, total body clearances ( Cl T ) were 88.96 ± 6.63 and 84.86 ± 4.95 mL/h/kg body weight and renal clearances ( Cl r ) were 0.52 ± 0.09 and 0.62 ± 0.18 mL/h/kg body weight. A hydroxylated metabolite of flunixin was identified by gas chromatography/mass spectrometry (GC/MS) under electron and chemical ionization and its major fragmentation pattern was verified by tandem mass spectrometry (GC/MS/MS) using neutral loss, daughter and parent scan modes. The detection times for flunixin and its hydroxylated metabolite in urine after an intravenous (i.v.) dose of 2.2 mg/kg body weight were 96 and 48 h, respectively.