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Sino‐aortic denervation augments the increase in blood pressure seen during paradoxical sleep in the rat
Author(s) -
SEI HIROYOSHI,
MORITA YUSUKE,
TSUNOOKA KIYOSHI,
MORITA HIRONOBU
Publication year - 1999
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1046/j.1365-2869.1999.00135.x
Subject(s) - denervation , blood pressure , sleep (system call) , medicine , cardiology , anesthesia , computer science , operating system
Summary Using a computer assisted telemetric system, we have re‐examined the effect of sino‐aortic denervation (SAD) on the changes in arterial blood pressure (AP) and heart rate (HR) during sleep in the rat suitably recovered from the operation. Eight 1 hourly polygraphic recordings were performed 4 weeks after the initial SAD surgery. In the SAD rats, the increase in AP during paradoxical sleep (PS) was much larger than that in sham‐operated rats. HR in the SAD rats increased on‐going from slow‐wave sleep to PS, but it showed no change in sham‐operated rats. The present study suggests that chronic SAD causes the enhanced AP increase during PS concomitantly with the persistent hypertension and tachycardia across sleep‐wake states.