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Blood pressure effects of long‐term stimulant use in disorders of hypersomnolence
Author(s) -
WALLIN MITCHELL,
MAHOWALD MARK
Publication year - 1998
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1046/j.1365-2869.1998.00110.x
Subject(s) - stimulant , medicine , blood pressure , term (time) , psychiatry , psychology , anesthesia , physics , quantum mechanics
Untoward cardiovascular effects have been implicated as a deterrent to long‐term central nervous system (CNS) stimulant use in disorders of hypersomnolence. In this study, we reviewed the relationship between blood pressure and long‐term stimulant use. Medical records of 54 patients with narcolepsy and idiopathic CNS hyper‐ somnolence (ICH) were reviewed. The overall mean number of months of follow‐up for the entire group was 45.6 (95% CI: 42–49). Both simple linear regression and multiple regression utilizing generalized estimating equations were used to show relationships between blood pressure (BP), time and other covariates. In the simple linear regression model, the average slope of the line of systolic BP (SBP) on time for the entire group was 0.06 (95% CI: ‐0.09, 0.13) and the line of diastolic BP (DBP) on time was 0.01 (95% CI: ‐0.05, 0.07). Two multiple regression equations were fitted for the continuous response variables SBP and DBP. Covariates in the model included: time, hypertension, weight at baseline, weight, SBP baseline (SBPBL), DBP baseline (DBPBL), high vs. low dose stimulant therapy and age at starting treatment. For SBP, the covariates weight at baseline, weight and SBPBL were significant ( P < 0.05) predictors. For DBP, covariates reaching statistical significance ( P < 0.05) included weight and DBPBL. There was no significant change in SBP or DBP over time in either model. Two different statistical models support the conclusion that there was no significant change in SBP or DBP over time in this population.