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The distribution of cyclooxygenase‐1 in human temporomandibular joint samples: an immunohistochemical study
Author(s) -
Yoshida H.,
Fukumura Y.,
Fujita S.,
Nishida M.,
Iizuka T.
Publication year - 2001
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1046/j.1365-2842.2001.00696.x
Subject(s) - immunohistochemistry , cyclooxygenase , temporomandibular joint , polyclonal antibodies , connective tissue , synovial membrane , prostaglandin , prostaglandin e2 , chemistry , arachidonic acid , pathology , medicine , antibody , enzyme , inflammation , immunology , biochemistry
Cyclooxygenase‐1,2 (COX‐1,2) or prostaglandin (PG) H synthase, is the first enzyme of the pathway in which arachidonic acid is oxidized to PGs. Thus, we examined the expression of COX‐1 in 16 human temporomandibular joint (TMJ) samples with internal derangement and in 10 control specimens by an immunohistological technique using paraffin‐embedded tissue and specific antihuman COX‐1 polyclonal antibody. There was obvious distinction of COX‐1 immunoreactivity between the control specimens and internal derangement cases, at the endothelial cells and fibroblasts, in the region of posterior and/or anterior loose connective tissues and synovial membrane. The findings of the present study suggest that COX‐1 might be an important mechanism for maintaining normal homeostasis at the endothelial cells and fibroblasts with internal derangement of TMJ.