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The expression of transforming growth factor beta (TGF‐ β ) in the synovial membrane of human temporomandibular joint with internal derangement: a comparison with tenascin expression
Author(s) -
Yoshida H.,
Yoshida T.,
Iizuka T.,
Sakakura T.,
Fujita S.
Publication year - 1999
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1046/j.1365-2842.1999.00461.x
Subject(s) - synovial membrane , temporomandibular joint , transforming growth factor beta , tgf beta 1 , synovitis , transforming growth factor , polyclonal antibodies , pathology , chemistry , medicine , immunology , antibody , inflammation , arthritis
We examined the expression of the transforming growth factor beta (TGF‐ β ) in 28 human temporomandibular joint (TMJ) samples (internal derangement of TMJ and control specimens) by an immunohistological method using paraffin‐embedded tissues and a polyclonal antibody specific to human TGF‐ β . The resulting reaction of TGF‐ β expression divided into three types as follows. The first type, around the fibrocyte and in the lacunae of chondrocytes in the disc. The second type, at the stroma of the mildly hypertrophic synovial membrane and severely hypertrophic synovial membrane. The first type was observed in all the cases including the control cases. The second type showed only in the internal derangement of TMJ, and its expression pattern resembled that of tenascin (TN) within the stroma of hypertrophic synovial membranes. In conclusion, TGF‐ β and TN were distributed in the affected synovial membrane of TMJ with internal derangement. These findings suggested that TGF‐ β and TN might have a close relationship with synovitis, followed by tissue repair.