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Depression, Stress and the Adrenal axis
Author(s) -
Carmine Pariante
Publication year - 2003
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.2003.01058.x
Subject(s) - hypothalamic–pituitary–adrenal axis , endocrinology , medicine , depression (economics) , psychology , adrenal function , hormone , economics , macroeconomics
Summary Depression is characterized by an over activity of the hypothalamic‐pituitary‐adrenal (HPA) axis that resembles the neuroendocrine response to stress. These HPA axis abnormalities participate in the development of depressive symptoms. Moreover, antidepressants directly regulate HPA axis function. These novel findings are reshaping our understanding of the causes and treatment of this disabling disorder.