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The Effects of the Phytoestrogen, Coumestrol, on Gonadotropin‐Releasing Hormone (GnRH) mRNA Expression in GT1‐7 GnRH Neurones
Author(s) -
Bowe J.,
Li X. F.,
Sugden D.,
Katzenellenbogen J. A.,
Katzenellenbogen B. S.,
O'Byrne K. T.
Publication year - 2003
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.2003.00991.x
Subject(s) - coumestrol , endocrinology , medicine , gonadotropin releasing hormone , antagonist , phytoestrogens , gonadotropin , receptor , hormone , messenger rna , biology , chemistry , estrogen , luteinizing hormone , gene , biochemistry
Phytoestrogens can produce inhibitory effects on gonadotropin secretion in both animals and humans, although little is known about the mechanisms and the role of direct action on oestrogen receptors (ER) in this process. We examined the effect of coumestrol, alone and combined with ER antagonists, on gonadotropin‐releasing hormone (GnRH) mRNA expression in GT1‐7 cells. Coumestrol was found to have an inhibitory effect compared to controls, which was blocked by R,R ‐THC, a selective ER β antagonist. These results suggest that ER β is involved in the suppression of GnRH mRNA expression by coumestrol.