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Neurosecretory and Non‐Neurosecretory Parvocellular Neurones of the Hypothalamic Paraventricular Nucleus Express Distinct Electrophysiological Properties
Author(s) -
Luther J. A.,
Daftary S. S.,
Boudaba C.,
Gould G. C.,
Halmos K. Cs.,
Tasker J. G.
Publication year - 2002
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.2002.00867.x
Subject(s) - parvocellular cell , hypothalamus , electrophysiology , nucleus , medicine , biology , neuroscience , endocrinology , cell bodies , central nervous system
Parvocellular neurones of the hypothalamic paraventricular nucleus (PVN) comprise neurosecretory and non‐neurosecretory subpopulations. We labelled neurosecretory neurones with intravenous injection of the retrograde tracer, fluoro‐gold, and recorded from fluoro‐gold‐positive and negative PVN parvocellular neurones in hypothalamic slices. Non‐neurosecretory parvocellular neurones generated a low‐threshold spike (LTS) and robust T‐type Ca 2+ current, whereas neurosecretory neurones showed no LTS and a small T‐current. LTS neurones were located in non‐neurosecretory regions of the PVN, and non‐LTS neurones were located in neurosecretory regions of the PVN. These findings indicate that neurosecretory and non‐neurosecretory subtypes of parvocellular PVN neurones express distinct membrane electrical properties.