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Clock Gene Protein mPER1 is Rhythmically Synthesized and Under cAMP Control in the Mouse Pineal Organ
Author(s) -
Von Gall C.,
SchneiderHüther I.,
Pfeffer M.,
Dehghani F.,
Korf H.W.,
Stehle J. H.
Publication year - 2001
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.2001.00643.x
Subject(s) - pineal gland , per1 , pinealocyte , biology , endocrinology , medicine , clock , messenger rna , endogeny , microbiology and biotechnology , gene , circadian rhythm , circadian clock , genetics
The mammalian clock gene Per1 is an important element of endogenous oscillators that control daily rhythms in central and peripheral tissues. Although such autonomous clock function is lost in the mammalian pineal gland during evolution, mPer1 mRNA and mPER1 protein were found to be strongly elevated in the mouse pineal organ during the dark period compared to daytime values. In vitro studies showed that mPer1 mRNA and mPER1 protein in mouse pineal gland are induced following the activation of a signalling pathway of fundamental importance for pineal physiology, the norepinephrine/cAMP/phosphoCREB cascade. mPER1 may function in the mouse pineal gland as a time‐measuring molecule to participate in regulating rhythmic cellular responses in vivo .