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Day and Night Dysfunction in Intraretinal Melatonin and Related Indoleamines Metabolism, Correlated with the Development of Glaucoma‐Like Disorder in an Avian Model
Author(s) -
Dkhissi,
Chanut,
VersauxBotteri,
Trouvin,
Repérant,
NguyenLegros
Publication year - 1998
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.1998.00273.x
Subject(s) - melatonin , quail , glaucoma , retinal , endocrinology , medicine , intraocular pressure , serotonin , biology , retina , biochemistry , ophthalmology , receptor , neuroscience
As previous studies have suggested that melatonin and serotonin may be involved in the regulation of intraocular pressure, retinal concentrations of melatonin, 5‐HT, and related indoleamines measured at day and at night were studied during the development of a glaucoma‐like disorder with increased intraocular pressure in the al mutant quail. Indoleamine levels were determined by HPLC with electrochemical detection in 1‐month‐, 3‐month‐, and 7‐month‐old al mutant and control quails. Morphology and numbers of melatonin‐synthesizing and 5‐HT‐containing cells, labelled immunohistochemically with an anti‐hydroxyindol‐0‐methyltransferase (HIOMT) antibody and an anti‐5‐HT antibody, respectively, were studied. Major findings were that: (1) no significant changes in morphology of melatonin‐synthesizing cells or in the morphology and density of 5‐HT‐containing amacrine cells were observed during the d velopment of glaucoma: (2) 5‐HT metabolism was modified during the night at 1 month of age and during the day after 3 months; and (3) melatonin metabolism was modified during the night at 7 months and during the day after 3 months. These results demonstrate a relationship between the temporal evolution of this avian glaucoma and a dysfunction in indoleamine retinal metabolism.