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Differential Distribution of Thyroid Hormone Receptor Isoform in Rat Dorsal Root Ganglia and Sciatic Nerve in vivo and in vitro
Author(s) -
Glauser L.,
Barakat Walter I.
Publication year - 1997
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.1997.d01-1088.x
Subject(s) - sciatic nerve , endocrinology , medicine , alpha (finance) , biology , sensory neuron , thyroid hormone receptor , gene isoform , immunolabeling , immunohistochemistry , anatomy , thyroid , central nervous system , construct validity , nursing , patient satisfaction , biochemistry , gene
Using autoradiographic techniques carried out under precise conditions we previously demonstrated that both sensory neurons and peripheral glial cells in dorsal root ganglia (DRG) or sciatic nerve, possess specific []> 125 I]‐labeled T 3 binding sites. Thyroid hormone receptors (TR) include several isoforms (TRα 1 , TRα 2 , TRβ 1 , TRβ 2...) The present study demonstrates that while sensory neurons and peripheral glial cells both possess functional TR, they express a differential expression of TR isoforms.