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Melatonin Inhibits GnRH‐Induced Increase of cFOS Immunoreactivity in Neonatal Rat Pituitary
Author(s) -
Vanecek Jiri
Publication year - 1997
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.1997.d01-1076.x
Subject(s) - medicine , endocrinology , melatonin , prolactin , hormone
In neonatal rat gonadotrophs, melatonin inhibits several GnRH‐induced effects: stimulation of LH release as well as the increase of several second messengers as cAMP, diacylglycerol and [ Ca 2+ ] i . Recently, GnRH has been shown to induce expression of immediate early genes of fos and jun family in adult rat gonadotrophs. The purpose of this study was to determine, whether melatonin inhibits the GnRH‐induced induction of cFos in neonatal rat pituitary cells.