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Rapid Changes of Heteronuclear RNA for Arginine Vasopressin but not for Corticotropin Releasing Hormone in Response to Acute Corticosterone Administration
Author(s) -
Ma XinMing,
Levy Andrew,
Lightman Stafford L.
Publication year - 1997
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.1997.00646.x
Subject(s) - endocrinology , vasopressin , medicine , corticosterone , arginine , corticotropin releasing hormone , copeptin , hormone , adrenocorticotropic hormone , chemistry , amino acid , biochemistry
Corticotropin‐releasing hormone and arginine vasopressin gene transcription were studied in the parvocellular cells of the hypothalamic paraventricular nucleus in response to both adrenalectomy and the injection of corticosterone. Following 6 days ADX, there was an increase in AVP mRNA, AVP hnRNA and CRH mRNA but not CRH hnRNA. After injection of corticosterone in ADX rats there was an extremely rapid reduction in AVP hnRNA which fell markedly within 15min. AVP mRNA, however, remained raised throughout the 4 h. CRH hnRNA fell at 2 and 4 h, while CRH mRNA was only significantly reduced at the 4 h time point. Data demonstrate markedly different kinetics for the glucocorticoid regulation of the AVP and CRH genes in the hypothalamus.