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The Interactive Language of the Hypothalamus for the Gonadotropin Releasing Hormone (GNRH) System
Author(s) -
Kalra Satya P.,
Horvath Tamas,
Naftolin Frederick,
Xu Bin,
Pu Shuye,
Kalra Pushpa S.
Publication year - 1997
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.1997.00619.x
Subject(s) - neurochemical , neuroscience , hypothalamus , inhibitory postsynaptic potential , synaptic plasticity , second messenger system , excitatory postsynaptic potential , gonadotropin releasing hormone , hormone , endocrinology , medicine , biology , receptor , secretion , luteinizing hormone
The enormous diversity in neurochemical signals employed within the network of afferents to GnRH neurons is well‐documented. An examination of novel and accumulating knowledge on the operation of these messengers indicates the presence of an interactive language governing GnRH secretion. The basic operational structures identified to date to affirm this interactive form of communication summarized in this review are the following: (i) the demonstration of interconnections within various components of the afferent network; (ii) coexistence and possible co‐release of excitatory and inhibitory neurotransmitters/ neuromodulators; (iii) co‐action of various messengers at synaptic targets, and (4) modulation by gonadal steroids of the synthesis and release of signals and their receptors, and induction of synaptic plasticity for the timely relay of signals for GnRH secretion. Unraveling the molecular sequelae that promote this interactive communication to elicit periodic GnRH secretion is now a new challenge.