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Progesterone Receptor Participates in the Stimulatory Effect of LHRH, Prostaglandin E2, and Cyclic Amp on Lordosis and Proceptive Behaviours in Rats
Author(s) -
Beyer Carlos,
GonzálezFlores Oscar,
GonzálezMariscal Gabriela
Publication year - 1997
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.1997.00617.x
Subject(s) - proceptive phase , medicine , endocrinology , ovariectomized rat , estrous cycle , lordosis behavior , luteinizing hormone , lordosis , prostaglandin e2 , receptor , antagonist , chemistry , hormone , estradiol benzoate , radiography , radiology
We explored the effect of the antiprogestin RU486 on the estrous behaviour (lordosis and proceptivity) induced in sexually experienced ovariectomized oestrogen primed rats by: 5 μg luteinizing hormone‐releasing hormone (LHRH), 100 μg prostaglandin E2 (PGE2), or 2 mg dibutyryl cyclic AMP (db cAMP). Pretreatment with 5 mg RU 486 (but not with vehicle) 60 min before the injection of the above‐mentioned agents significantly decreased both lordosis and proceptive behaviours normally induced by such agents. Results suggest that the estrus‐inducing action of LHRH, PGE2 and db cAMP occurs through the activation of the progesterone receptor.