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Neonatal Maternally Deprived Rats have as Adults Elevated Basal Pituitary‐Adrenal Activity and Enhanced Susceptibility to Apomorphine
Author(s) -
Rots Nynke Y.,
de Jong Jeannette,
Workel Judith O.,
Levine Seymour,
Cools Alexander R.,
De Kloet E. Ronald
Publication year - 1996
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.1996.04843.x
Subject(s) - endocrinology , medicine , apomorphine , basal (medicine) , dopamine , stimulation , maternal deprivation , period (music) , corticosterone , hormone , dopaminergic , insulin , physics , acoustics
Maternal deprivation of neonatal rats for 24 h enhances the adrenocortical response to stress and/or adrenocorticotropin hormone (ACTH) stimulation during the stress hyporesponsive period (SHRP). The present study tests the hypothesis that such maternally deprived neonatal male rats show altered hypothalamic‐pituitary‐adrenal (HPA) regulation not only immediately after deprivation but also in later life. In addition, we found previously that neonatal changes in HPA activity preceded modulation of nigrostriatal dopamine function. Therefore, we also measured dopamine responsiveness in adult rats which were deprived of their mother during infancy.