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Adverse renal effects of anti‐inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors
Author(s) -
Gambaro G.,
Perazella M. A.
Publication year - 2003
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2003.01146.x
Subject(s) - medicine , cyclooxygenase , nephrotoxicity , adverse effect , nephrology , pharmacology , kidney , enzyme , biochemistry , chemistry
. Gambaro G, Perazella MA (Division of Nephrology, University Hospital, Padua, Italy; and Section of Nephrology, Yale University, New Haven, CT, USA). Adverse renal effects of anti‐inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors (Review). J Intern Med 2003; 253 : 643–652. Conventional nonsteroidal anti‐inflammatory drugs (NSAIDs), i.e. nonselective cyclooxygenase COX inhibitors have well‐documented nephrotoxicity. Adverse renal effects occur because of inhibition of the synthesis of cyclooxygenase‐derived prostaglandins which act to modulate pathologic processes that would normally impair various renal functions. The introduction of the selective COX‐2 inhibitors raised hope that this class of drugs would reduce injury in both the gastrointestinal tract and the kidneys. Animal and human data, however, suggest that COX‐2 synthesized prostaglandins are important in the modulation of renal physiology during adverse conditions. Hence, it appears that these drugs are equal in causing nephrotoxicity as the nonselective COX inhibitors.