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Accelerated usual interstitial pneumonitis, anti‐DNA antibodies and hypocomplementemia
Author(s) -
Schattner A.,
AvielRonen S.,
Mark E. J.
Publication year - 2003
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2003.01144.x
Subject(s) - medicine , idiopathic pulmonary fibrosis , pneumonitis , usual interstitial pneumonia , interstitial lung disease , pathology , pulmonary fibrosis , autopsy , lung , fibrosis
. Schattner A, Aviel‐Ronen S, Mark EJ (Kaplan Medical Center, Rehovot and Hebrew University‐Hadassah Medical School, Jerusalem; Sheba Medical Center, Tel‐Hashomer, Israel; and Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA). Accelerated usual interstitial pneumonitis, anti‐DNA antibodies and hypocomplementemia (Case Report). J Intern Med 2003; 254: 193–196. A healthy 60‐year‐old patient presented with progressive dyspnoea. Clinical, radiographic and pathological features of interstitial lung disease were found and an open lung biopsy established the diagnosis of usual interstitial pneumonitis (UIP) (idiopathic pulmonary fibrosis). Despite treatment, the patient died 4 months later in respiratory failure. Although the patient had no extra‐thoracic involvement at autopsy, his illness was associated with a very high titre of anti‐double‐stranded DNA antibodies, hypocomplementemia, hypergammaglobulinaemia and lymphoid hyperplasia. These features and a literature review, suggest immune‐mediated lung damage in a subset of patients with UIP.